HIGH-THROUGHPUT NOVEL ANTIMICROBIAL DISCOVERY FROM 'OMIC DATASOURCES
AMPLY is in its infancy. The long lead times for the generation of published papers (especially where a significant amount of the content needs IP protection) means that 2019 is the first year where research will begin to be released in volume. But AMPLY has already been recognised as a highly interesting and productive novel drug discovery platform.
Life Sciences Research Network Award: Best PhD Presentation (2018)
Life Sciences Research Network Award: Runner Up Best Postdoc Research Talk (2016) – (presented by collaborator Dr Lucy Onime)
Poster Award - IMA International Mycological Association for highlighting anaerobic fungi AMP work (presented by a collaborator Rebeca Evans)
Highlight project (Welsh Government) – October 2018
Software and data processing
Other key contributors to the AMPLY pipeline:
Sharon Huws, Queen's University, Belfast (AMP specialist)
Jurnorain Gani, St. George's Hospital, Tooting, London (in vitro testing)
Kai Hilpert, St. George's Hospital, Tooting, London (in vitro testing/Tika Diagnostics CEO)
Mandy Wooton, Public Health Wales Microbiology Cardiff. University Hospital of Wales (in vitro testing)
Nick Dimonaco (ORF finding software, Aberystwyth University)
Jess Friedersdorff (bacteria, HAPs, viruses, memes)
Karen Siu Ting (novel transcriptome recovery/amphibian specialist)
Linda Oyama, Queen's University, Belfast (AMP specialist)
Beca Adams, Aberystwyth University (in vitro fungal testing)
Gareth Griffith, Aberystwyth University (anerobic fungi specialist)
AMPLY is currenty deployed in a number of projects with partners. For reasons of confidentiality details on many of these projects cannot be shared at this time.
Recent (and upcoming) conferences
Some recent papers from the AMPLY group:
Wilkinson, T. J., Huws, S. A., Edwards, J. E., Kingston-Smith, A. H., Siu-Ting, K., Hughes, M., ... & Creevey, C. J. (2018). CowPI: a rumen microbiome focussed version of the PICRUSt functional inference software. Frontiers in microbiology, 9.
Huws, Sharon A., Christopher J. Creevey, Linda B. Oyama, Itzhak Mizrahi, Stuart E. Denman, Milka Popova, Rafael Muñoz-Tamayo et al. "Addressing global ruminant agricultural challenges through understanding the rumen microbiome: Past, present, and future." Frontiers in microbiology 9 (2018).
Benjamin J Thomas, Bacterial and Eukaryotic AMPs, Wiley Encyclopaedia of Life Science (http://www.els.net/WileyCDA/)
Thomas C.A. Hitch, Benjamin J. Thomas, Jessica C.A. Friedersdorff, Helen Ougham, Christopher J. Creevey, Deep sequence analysis reveals the ovine rumen as a reservoir of antibiotic resistance genes, Environmental Pollution, Volume 235, April 2018, Pages 571-575